IAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis

James E. Vince,1 W. Wei-Lynn Wong,1,8 Nufail Khan,1,8 Rebecca Feltham,1,8 Diep Chau,1 Afsar U. Ahmed,1 Christopher A. Benetatos,2 Srinivas K. Chunduru,2 Stephen M. Condon,2 Mark McKinlay,2 Robert Brink,3 Martin Leverkus,4 Vinay Tergaonkar,5 Pascal Schneider,6 Bernard A. Callus,1 Frank Koentgen,7 David L. Vaux,1 and John Silke1,* 1Department of Biochemistry, La Trobe University, Kingsbury Drive, Melbourne, VIC 3086, Australia 2TetraLogic Pharmaceuticals, 343 Phoenixville Pike, Malvern, PA 19355, USA 3Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia 4Laboratory for Experimental Dermatology, Department of Dermatology and Venerology, Otto-von-Guericke-University Magdeburg, Germany 53-02B, IMCB, 61 Proteos, Biopolis Drive, Singapore 138673 6Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland 7Ozgene Pty Ltd P.O. Box 1128 Bentley DC, Western Australia 6983, Australia 8These authors contributed equally to this work. *Correspondence: [email protected] DOI 10.1016/j.cell.2007.10.037